This proposal is for support to develop a specialized cancer center at Purdue University whose primary objectives are to correlated and integrate existing programs in cancer research at Purdue University, to stimulate new research in selected areas, to contribute to advanced training in cancer research, and to develop interactions among Purdue researchers, local physicians, hospitals and clinics and cancer researchers at other universities and research laboratories within the State of Indiana. Commitment is to the development of a multidisciplinary program of experimental cancer research with focus on the biological and biochemical events involved in cell transformation as the basis for new approaches to the prevention, diagnosis and chemical therapy of cancer.